Loosely based on these comics.
While no one will hold a candle to J.K. Simmons' J. Jonah Jameson, I'd like to see the character back in the films. He could be a newspaper editor/cable news editorial host who likes to stir controversy. The most public backer for the super hero registration act in the MCU.
He turns most of NYC on Spidey and launches a huge smear campaign. Until, Spidey just happens to save Jameson's son from some incident.
Losing face he tries to spin the facts and make Spidey look like the villain, meanwhile investing in "Hero Slayers." A special robotics task force he's backing financially to be the new police force against non-registered heroes created by Spencer Smythe. (Like Sentinels to mutants.) He plans to do this after he gets himself or his son on the ticket for next year's mayor campaign.
A few "Spider Slayers" are sent Parker's way - each deadlier than the last - but he deals with them all.
Spidey starts becoming a hero to the public again and Jameson's newspaper sales and ratings are going down. Jonah decides to back a hero of his own making that can also be "the ultimate spider slayer" at the same time.
Enter Mac Gargan becoming Scorpion.
Conning Spider-Man out into the open publicly, Scorpion is made to be a bigger hero than Spidey. On two occasions he provokes Spidey into fighting him. After the first fight Spidey is beaten up and humiliated. On the second, Gargan's scorpion aggression really kicks in and he nearly kills Spidey. The city, and even Jameson, turns on Gargan and Gargan goes nuts.
Scorpion makes a plan to expose Jameson. He goes to the Smythe factory to live stream the truth. Jameson shows up telling Smythe to shut it all down before he's exposed. Scorpion takes Spencer Smythe and Jameson hostage. Spidey sees the stream and goes to stop Scorpion, but gets taken down for a third time. During the fight, Gargan shackles Spidey and Jameson together with the shackle bomb Smythe made to restrain Spider-Man. The shackle also releases an EMP that takes out Spidey's high tech suit.
Meanwhile, Scorpion forces Spencer Smythe to turn the Slayers on the citizens of NY. Spencer refuses, so Scorpion grabs his son Alistair and breaks the kid's back. He threatens to finish Alistair if Spencer doesn't do it. Scorpion then allows Spidey to go and stop them, but has to take Jameson with him, obviously. Spidey has a short amount of time to save as many people as he can while trying to free himself and/or stop the bomb from going off. Jonah bickering the whole way. What everyone doesn't know, is that Scorpion has a remote control to set the bomb off even if saves everyone in time.
Meanwhile, several camera drones are programmed to follow Spidey/Jonah - for Scorpion's live stream feed. All Spidey and the NYPD are distracted, Scorpion pulls off a heist of some kind. He takes Spencer with him as a hostage while checking the stream on his phone to see how Spidey and Jonah are doing.
Eventually, Spidey breaks free and saves Jonah along the way, while stopping the slayers. Luckily, Scorpion's too distracted at the time with the heist to notice Spidey and Jonah getting free with seconds to spare. (Here we can work in some last moment drama that the bomb goes off thanks to the remote before Spidey can properly dispose of it and some innocent people get hurt. Jameson can either turn the blame on Spidey or take it on himself at the end of the movie as a "thank you.")
Alistair manages to patch into Spidey's com link from the factory now that the costume is back on-line. He tells Spidey where Scorpion went and makes Spidey promise to save his father. Spidey promises.
Spidey confronts Scorpion - major fight breaks out. Being too tough to fight head-on, Spidey eventually outsmarts Scorpion to win, however is unable to save Spencer.
We cut to one year later. J. Jonah Jameson is in hiding from the public. The Daily Bugle goes out of business with many losing their jobs - Peter blames himself. (Earlier in the movie we can work in that Parker was doing an internship at the Bugle or that Aunt May works there to make a more personal connection.)
John Jameson continues to run for mayor anyway, but is too disgraced by association to his father to win.
Alistair Smythe - now angry at the world and Spider-Man for not being able to save his father - takes a meeting with the new mayor with some plans on how to get revenge on Spider-Man and the Jameson family. Also, on how to keep the super hero community in NYC in check.
The meeting is with newly elected Mayor Rodrick Kingsley.
End movie.
(Obviously, there'd be some high school drama stuff in there too, but that's my rough idea.)