Without question nor hesitation I say NEGATION was the brightest star in the Crossgen line. Like I have said, it is responsible for bringing me back to comics after the early 90's drove me away screaming.
If I were to put a grade ... or order of greatness
... I would say
NEGATION (Tony Bedard and Paul Pellitier ... both are okay on their own, but together they were incredible)
RUSE (F'n Sherlock type character with a wise ass/god as a helper ... hahaha)
MERIDIAN (Really worked well with the Sigil's, plus McNiven art !!)
SCION (Just for Cheung I believe)
THE FIRST (was really fun read, but GOD THE ART SUCKED!!!! Bart Sears !!!! UUUGGG)
SIGIL (I liked Sam
and the art got waaay better)
CRUX (Good Atlantis survivor story)
SOJOURN (My first foray into Greg Land ... I was blown away ... at first ...)
MYSTIC (for awhile)
ROUTE 666 (was fun ... in a Ghost Rider/Son of Satan kind of way)
WAY OF THE RAT (was funny at times ... can't remember the damn monkey's name though)
KISS KISS, THE PATH, CHIMERA (which I hated), SOLUS (which was confusing) and all the later titles kind sucked just because the company was falling apart by then, and I lost my love affair with the idea of Crossgen ... DAMN THEM)
El Cazador and Brath were pretty good also.
(Crap, keep forgetting to add BRATH to my want list )